Pixel Art Workflow (Patreon)
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Never tried it before, but I've seen people explain the general workflow. Basically, you draw at very low resolution and then blow up the image.
I made each character on a 64 x 64 px canvas in Photoshop using the old-school pencil tool, which just stamps solid pixels. I first drew in black, then went over the pixels with different colors, establishing a limited palette. At this scale it feels less like drawing and more like assembling a puzzle. Figuring out how to indicate small details is surprisingly fun and intuitive.
Once an initial standing pose was drawn, I used extra layers do make other poses. This is what my first attempt looked like:

But it felt messy. I realized the design needed to be neater and more symmetrical. So I put Captain D aside and drew the other characters to start fresh. The poses for Adam and Korney were an improvement:


For front angles, it helped to draw one side and then just mirror. After getting the hang of it, I went back to CD and was a bit more generous with the animation phases. He is the hero, after all.

In a way, drawing a detailed character in pixels is easier than drawing a simple, smooth shape. I wasn't sure how to depict a soccer ball and animate it spinning without ending up with a blob of wiggling pixels. So I took a different approach:

I modeled a sphere in Blender, shaded it with the pattern, made a 4-frame looping spin animation and rendered it at 64 x 64 pixels in lowest possible sampling quality so there was no antialiasing. The result fit well with the rest of the artwork:

After drawing the goal net using the same method as the characters, I took the images into After Effects and magnified everything 500%, making sure to switch each layer to low quality to avoid pixel blending. (In modern software it takes extra effort to keep things in low quality!)
I first assembled the character layers into animated comps, then positioned all the elements on the screen in a master comp.

The rest of the environment and text was made directly in AE. A simple pattern of dots indicating grass was cloned across the screen using the "motion tile" effect. The graphics were generated normally then degraded with a combination of the "mosaic" and "block load" effects.

The whole process is time-consuming, but not as tedious as it may seem. And the results are worth it. I might try it again in the future!
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