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Bonus Audio: Scott's Weight Loss Journey Part 2 (Patreon)

Published:
2026-08-01 06:05:48
Imported:
2026-08
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GO HERE TO LISTEN TO PART 1 OF THIS PODCAST SERIES

In May 2024, I recorded a bonus Patreon podcast episode with my friend Scott, who had just started to take Zepbound. I wanted to hear about what led him to that point and what the impact of the decision had been. I meant to record a follow-up to that podcast six months later, but you know how life can get.

Now it's summer 2026 and some recent doctor's visits have led me to the point where it seems like a GLP-1 might be a good next step for me. So I invited Scott back to share what his experience has been over the past two years. We discuss:

How much weight Scott has lost while taking Zepbound for 2+ years

What are the primary side effects he's experienced

How Zepbound has changed his personality

Whether he'll continue taking it moving forward

Tips and tricks for how he's made the most of his time on Zepbound

I hope you find the episode interesting (and if you don't, feel free to let me know!). This will not be a major podcast series on this Patreon but if I do proceed down the path of taking a GLP-1, I will record at least one additional follow-up to this episode.

As always, your feedback and support are welcome and appreciated. Thanks for supporting me here so I can record and publish off-topic conversations like this one!

NOTE: This podcast does not constitute medical advice, nor is it an endorsement of any of the techniques/medications discussed. Neither of us are medical professionals. If you’re interested in any topics discussed, talk to your doctor.

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Comments

Satorii

This was an excellent podcast. Thank you for doing this update. I have been using compounded zepbound as well, mainly for weight loss but for anti-inflammation. Apparently there are studies that are going through the FDA right now that might approve these sorts of GLP-1 drugs to help with inflammation. I also have a very rare genetic condition that basically leaves me inflamed flushed, hot to the touch skin and bright red at all times. I have definitely noticed weight loss, about 40 lbs. in 1.5 years as a cis female. I'm not sure if inflammation has gone down but I do think it is helping slightly. I should start a journal like Scott for my flushing Times (the only thing that has been stopping me from doing that is that it happens all the time so I will be having to write it down so often)! @david I would be more than happy to chat if you are interested about my experience as well. I have only used the compounded vial option because Insurance would not approve my reasons as well.

Satorii

Oh, and again as a cis female, having lost 40 pounds I definitely do get treated differently still even as a middle-aged woman lol and sad at the same time

Iain Clarke

I am also doing this, but in Europe. We have a health service, but this is out of pocket - so that's an unaccustomed expense for me! I'm a few months in, and have lost an inch and a few kgs - but also in the early days as they ramp up the dose. Apparently there can be unlikely but nasty side effects with the pancreas, so they start gently. I've not had an issues there! It has given me terrible diarrhea - so I have shifted the day of week I take my dose so I can be sure to be working at home for the two days after. Luckily I work from home most days, so that's not a burden. I assume that's similarly not a blocker for you as a podcaster. It has improved for me too, so I hope this is temporary. I received two tips when I picked up my recent doses from the pharmacist: 1/ Drink lots, but not just water - I should put in powder to make it easily absorbed, with electrolytes. Mostly to counter act tummy issues. 2/ Multivitamins. Eating less also means eating less good stuff. That might just have been a pharmacy upsell, but it makes some sense. I'll be asking at my next remove medical check on that. Thanks for an interesting show this week!

Osamah Abdullatif (edited)

Comment edits

2026-09-13 13:00 I’ve been on Mounjaro for 7 months now under doctor’s supervision. I’ve lost 27kg (approx 60lbs). I’m currently exactly where my doctor predicted I would be in six months. According to most studies Mounjaro users lose 20-25% of body weight over a year and a half. I’m presently at 21% but going by experience of people like Scott and people on Reddit many go as much as 50%. I’m quite sure I’m not what they call a “super responder”. I’ve had to titrate every two to three months and I’m presently on 12.5mg. I wish I could have been one of those who stay on 5mg or 7mg for months and months. Luckily I don’t have the terrible side effects I keep hearing about except constipation which comes and goes but easy to deal with meds like miralax. I started the GLP1 after a health scare. I first when on a low carb high protein diet and also quite drinking then started the shots about ten days later. I know many people who take the drug and let it control their eating. I controlled my eating first then took the drug so I can’t say how much of the result is purely the shots and how much is the change I made, especially the stopping of alcohol. I never had a problem with food noise, but I find that some weeks it seems like the shot doesn’t work and has an almost opposite effect. It’s happened two or three times over the past 7 months that within 48 hours of taking the shot not only am I getting hungry but my brain is barraging me with a constant stream of “I’m hungry. Why aren’t you eating? You should go get food”. I never had thoughts like those even at my most obese stage. I’ve been able to deal with it but it takes a lot of will power. Luckily it’s been a few months since I had one of those, but it scares me that maybe if I ever stop the shots or if I reach the stage when it stops working completely and there is no higher dose to titrate to I’ll have to deal with such thoughts and lose it. I’ve now met my initial target of losing 25kg and seeing just two figures on the scale. Now comes the stage of setting the next target. I’ve been a big guy all my life. I can’t see myself as a thin person so I don’t want to lose too much more. For example I’m happy with 36 inch waist. I’d rather not go down to a 34 or 32 but tone the rest of my body to look good at that size. I need to get working physically because thus for it’s been just the diet and the shots that did all the work. Dave, if you do start the shots I think you shouldn’t worry too much. You already do weights and live in an extremely walkable city with lots of outdoor activities unlike me here in the Middle East where it’s basically hell outside. Get the Glapp app for tracking your shots and weight loss. It’s amazing. And link your scale, health tracker, etc to Apple Health. I use a Whoop which I got as a gift to track sleep and heart rate and connected blood pressure monitor as well as a Eufy Scale. For me the weight loss is also for heart health and improved blood sugar control. It’s nerdy but I like when I go to the doctor every 8-10 weeks for blood work to have all the data to show and discuss. Sorry for the long response. Good luck and all the best.
2026-08-04 07:56 I’ve been on Mounjaro for 7 months now under doctor’s supervision. I’ve lost 27kg (approx 60lbs). I’m currently exactly where my doctor predicted I would be in six months. According to most studies Mounjaro users lose 20-25% of body weight over a year and a half. I’m presently at 21% but going by experience of people like Scott and people on Reddit many go as much as 50%. I’m quite sure I’m not what they call a “super responder”. I’ve had to titrate every two to three months and I’m presently on 12.5mg. I wish I could have been one of those who stay on 5mg or 7mg for months and months. Luckily I don’t have the terrible side effects I keep hearing about except constipation which comes and goes but easy to deal with meds like miralax. I started the GLP1 after a health scare. I first went on a low carb high protein diet and also quit drinking then started the shots about ten days later. I know many people who take the drug and let it control their eating. I controlled my eating first then took the drug so I can’t say how much of the result is purely the shots and how much is the change I made, especially the stopping of alcohol. I never had a problem with food noise, but I find that some weeks it seems like the shot doesn’t work and has an almost opposite effect. It’s happened two or three times over the past 7 months that within 48 hours of taking the shot not only am I getting hungry but my brain is barraging me with a constant stream of “I’m hungry. Why aren’t you eating? You should go get food”. I never had thoughts like those even at my most obese stage. I’ve been able to deal with it but it takes a lot of will power. Luckily it’s been a few months since I had one of those, but it scares me that maybe if I ever stop the shots or if I reach the stage when it stops working completely and there is no higher dose to titrate to I’ll have to deal with such thoughts and lose it. I’ve now met my initial target of losing 25kg and seeing just two figures on the scale. Now comes the stage of setting the next target. I’ve been a big guy all my life. I can’t see myself as a thin person so I don’t want to lose too much more. For example I’m happy with 36 inch waist. I’d rather not go down to a 34 or 32 but tone the rest of my body to look good at that size. I need to get working physically because thus for it’s been just the diet and the shots that did all the work. Dave, if you do start the shots I think you shouldn’t worry too much. You already do weights and live in an extremely walkable city with lots of outdoor activities unlike me here in the Middle East where it’s basically hell outside. Get the Glapp app for tracking your shots and weight loss. It’s amazing. And link your scale, health tracker, etc to Apple Health. I use a Whoop which I got as a gift to track sleep and heart rate and connected blood pressure monitor as well as a Eufy Scale. For me the weight loss is also for heart health and improved blood sugar control. It’s nerdy but I like when I go to the doctor every 8-10 weeks for blood work to have all the data to show and discuss. Sorry for the long response. Good luck and all the best.

I’ve been on Mounjaro for 7 months now under doctor’s supervision. I’ve lost 27kg (approx 60lbs). I’m currently exactly where my doctor predicted I would be in six months. According to most studies Mounjaro users lose 20-25% of body weight over a year and a half. I’m presently at 21% but going by experience of people like Scott and people on Reddit many go as much as 50%. I’m quite sure I’m not what they call a “super responder”. I’ve had to titrate every two to three months and I’m presently on 12.5mg. I wish I could have been one of those who stay on 5mg or 7mg for months and months. Luckily I don’t have the terrible side effects I keep hearing about except constipation which comes and goes but easy to deal with meds like miralax. I started the GLP1 after a health scare. I first went on a low carb high protein diet and also quit drinking then started the shots about ten days later. I know many people who take the drug and let it control their eating. I controlled my eating first then took the drug so I can’t say how much of the result is purely the shots and how much is the change I made, especially the stopping of alcohol. I never had a problem with food noise, but I find that some weeks it seems like the shot doesn’t work and has an almost opposite effect. It’s happened two or three times over the past 7 months that within 48 hours of taking the shot not only am I getting hungry but my brain is barraging me with a constant stream of “I’m hungry. Why aren’t you eating? You should go get food”. I never had thoughts like those even at my most obese stage. I’ve been able to deal with it but it takes a lot of will power. Luckily it’s been a few months since I had one of those, but it scares me that maybe if I ever stop the shots or if I reach the stage when it stops working completely and there is no higher dose to titrate to I’ll have to deal with such thoughts and lose it. I’ve now met my initial target of losing 25kg and seeing just two figures on the scale. Now comes the stage of setting the next target. I’ve been a big guy all my life. I can’t see myself as a thin person so I don’t want to lose too much more. For example I’m happy with 36 inch waist. I’d rather not go down to a 34 or 32 but tone the rest of my body to look good at that size. I need to get working physically because thus for it’s been just the diet and the shots that did all the work. Dave, if you do start the shots I think you shouldn’t worry too much. You already do weights and live in an extremely walkable city with lots of outdoor activities unlike me here in the Middle East where it’s basically hell outside. Get the Glapp app for tracking your shots and weight loss. It’s amazing. And link your scale, health tracker, etc to Apple Health. I use a Whoop which I got as a gift to track sleep and heart rate and connected blood pressure monitor as well as a Eufy Scale. For me the weight loss is also for heart health and improved blood sugar control. It’s nerdy but I like when I go to the doctor every 8-10 weeks for blood work to have all the data to show and discuss. Sorry for the long response. Good luck and all the best.

Mads Olsen

Very interesting topic. I work as an engineer in one of these big GLP-1 companies, but I rarely hear from the people taking the medicines we produce. Always nice to hear that your work has a positive impact on peoples lives! A little edit: I think you have a good base, David, with your strength training. Resistance training and high protein diet is a very good way to retain a lot of muscle while losing weight. Recent studies suggest that you should actually continue with high resistance strenth training (here’s one https://journals.physiology.org/doi/full/10.1152/ajpcell.00365.2021)., and not do low weights but a ton of reps. You’re better off doing either, but don’t be scared of heavier weights! As long as you don’t experience pain, then you should be good!

Warpstone

I'll be interested to hear about your journey if you decide to take this drug due to how varied everyone's experience is. Best of luck if you do decide to take it.

Nizar B

I didn't know I needed this update. Glad to hear Scott's been doing well (for the most part) with the drug. Hearing how you progress with it once you start would be interesting as well. Good luck, DC

Nathaniel St. Clair

Definitely interested in this conversation and your potential journey with it, Dave. This reminded me of the episode you did about hair loss. Which I also thought was great. Just digging into a subject that is impacting you, and also impacts many others.