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The Placebo Effect (Patreon)

Published:
2026-03-23 17:00:13
Imported:
2026-03

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A placebo (/pləˈsiːboʊ/ pluh-SEE-boh) is a medicine or treatment intended to appear genuine to its recipient, but which has no pharmaceutical effect.[1][2] Common placebos include inert tablets (like sugar pills), inert injections (like saline), sham surgery,[3] and other procedures.[4]

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Gilmore Snout

I work in an emergency room, and when we start an IV, we flush it with Saline to ensure it’s working. People often mistake the saline for medication, and will often relax as though they are about to experience pain relief. Usually, shortly afterward, they will ask how long it takes for the medicine to kick in, because they aren’t experiencing the pain relief they were expecting. That saline/morphine story smacks of someone who has never worked in an environment like that before. People can tell you didn’t give them anything.

Andrew Nielsen

I understand that Marsh is responding to claims that the placebo effect is not magically powerful, not, for example, as effective as surgery or as an inhaler. But I feel like criticism of the placebo study that found placebos were effective even when you were told they were a placebo, that they were "primed" by being told that placebos were effective seems...odd. I mean, isn't the placebo effect primarily about psychological priming? It seems like controlling for that kind of priming would just be...controlling for the placebo effect in a study about the placebo effect.

Fame and fortune guaranteed in the state of Tintucky

@24:05 or we are all sheeple who can be more easily fooled than critical thinking Boomers 60 years ago... or the benefit of Trumdemdyfinium by happy sunshine pharmaceuticals is 5% less rectal bleeding with an increased chance of internal bleeding and homicidal psychosis. Marginal to the point of pointlessness, like the quantum limit on transistors.

Menno

His point is that the placebo effect isn’t an effect. It’s the accumulation of all measurement biases in the study giving the illusion of an effect.

Andrew Nielsen

But psychological priming is effectively what is meant by the placebo effect, that if people believe they are doing something that will create an effect, they will be more likely to feel those effects. If psychological priming can create that effect, which is his argument against the study showing even knowing placebos can be effective, that just...is what people mean by the placebo effect.

Maeve

*Most ulcers are caused by H pylori, but some have otter causes, including NSAID usage. End pedantry.